Metabolic Control Theory

This page describes the application of some control theory concepts to metabolic regulation. It covers allosteric enzymes, covalent modification of proteins, futile cycles, regulation of gene expression and the sequestration of enzymes and substrates within compartments. Biochemical feedback loops are discussed in terms of reference values, error signals, closed loop gain, internal phase shifts and stability criteria. Input and output impedances are derived for metabolic processes, and it is shown how biologically advantageous control systems are often constrained by conventional engineering criteria. Many applications of these concepts can be seen in the separate page on the overall integration of liver metabolism. Click here to skip over the detailed contents section.

Detailed table of contents

allosteric enzymes
Bode plots
closed loop control
covalent modification
derivative control
error amplifier
feedback loops
futile cycles
integral control
gene expression
loop gain
phase delays
proportional control
sequestration
stability
substrate concentrations


Closed loop control systems


[This page is still under construction]

allosteric enzymes
Bode plots
covalent modification
derivative control
error amplifier
feedback loops
futile cycles
integral control
gene expression
loop gain
phase delays
proportional control
sequestration
stability
substrate concentrations


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