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This interactive flowchart shows the compartmentation and regulation of some major metabolic pathways in mammalian liver. It is specific for parenchymal cells and other tissues may be different. The reactions are colour-coded: pink for regulatory enzymes, blue for enzymes whose flux is limited by substrate availability, green for enzymes that operate close to equilibrium and yellow where there is insufficient kinetic data to decide. Point (don't click) the mouse at these coloured hotspots to display brief explanations about each enzyme. Click here for detailed instructions.
The flowchart is too big to display all at once on most computers, but you should be able to scroll horizontally and vertically across it. Click the white space to return to the top of the chart. If you click some of the coloured hotspots you may be taken to a more detailed explanation, but this feature is still under development and is not complete. You might wish to re-size the message windows if your browser uses very large or very small fonts. Normally the browser removes each message as the mouse moves off the link, but if you press any key it will keep the current message on the screen. You can then drag the window borders to the desired positions with the mouse. Your browser will automatically apply a similar correction to all subsequent messages. Most web browsers will not print the whole map, but click HERE to download a resizable copy in Adobe Acrobat portable document format (.pdf) which can be formatted to fit onto one A4 page. You should be able to print this quite easily.
If you have comments, queries or suggestions, email me at J.A.Illingworth@leeds.ac.uk