ubiquinol + 2 cytochrome C+++ + 2H+(in) => ubiquinone + 2 cytochrome C++ + 4H+(out)
This enzyme consists of eleven polypeptide chains, only one of which is coded by the mitochondrial DNA. The remaining subunits are imported from the cytosol. The two core subunits (I & II) do not contain redox centres but are essential for the proper assembly of the whole complex. The mitochondrial subunit III contains two heme b prosthetic groups which differ considerably in redox potential. Subunit IV (cytochrome c1) contains a further heme c, and subunit V contains an iron-sulfur cluster. Subunits III, IV and V are present in the molar ratios 2:1:1. The iron sulfur cluster and cytochrome c1 (which donates electrons to the soluble, low molecular weight cytochrome c) are both present on the cytosolic face of the inner membrane.
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