MB ChB Year 1: Nutrition and Energy

Lecture 5: Secretion 1

Dr Malcolm Hunter

Sympathetic or parasympathetic stimulation; composition and cellular origin of the various components; the two-stage hypothesis of salivary secretion. the cellular basis of acid secretion; active K+/H+-exchange; the protective bicarbonate/mucus barrier mechanism; induction and prevention of ulceration; control of gastric acid secretion (cephalic, gastric and intestinal); components of pancreatic secretion (enzymes and electrolytes); reciprocal relationship between the concentrations of bicarbonate and chloride in pancreatic juice and flow rate-dependence; cephalic, gastric and intestinal phases of control; the life-cycle of enterocytes; c-AMP and secretory diarrhoea of cholera.

Dr Hunter's Powerpoint presentations are available on the VLE.

Recommended reading

Gastrointestinal physiology 6th edn. by Leonard R. Johnson, Mosby, c2001

Physiology 5th edn. by Berne & Levy (Chapters 37, 38 & 39) Mosby, 2005

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