Insulin effects on glucose transport

1 Insulin causes receptor autophosphorylation 2 Activated insulin receptor phosphorylates IRS-1
3 Phosphorylated IRS-1 activates PI-3 kinase 4 PI-3 kinase converts PIP2 => PIP3 (activates PDK1)
5 PDK1 activates protein kinase B (PKB) 6 PKB stimulates GLUT-4 translocation

Some events take place on the membrane surface, because the lipid messengers are not soluble in water. Use the back button to return to the main document.

Glossary
IRS-1insulin receptor substrate 1
PDK13-phosphoinositide dependent kinase 1
PI-3Kphosphatidylinositol 3 kinase
PIP2phosphatidylinositol 4,5 bisphosphate
PIP3phosphatidylinositol 3,4,5 trisphosphate
PKBprotein kinase B


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