Insulin effects on glycogen storage

In resting (unstimulated) cells, glycogen synthase kinase 3 (GSK3) phosphorylates and inactivates glycogen synthase (GS), as shown in the diagram below. Reactivation of GS is catalysed by protein phosphatases, but these are less active than GSK3, so very little GS is present in the active form. [Scroll down.]

1    PKB is activated as described for glucose transport.
2    Activated PKB phosphorylates and inactivates GSK3.
3    Phosphatases reactivate glycogen synthase after the inhibitory pathways are disabled.

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Glossary
GSglycogen synthase
GSK3glycogen synthase kinase 3
PKBprotein kinase B


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